Headache Evidence
Guidelines and key evidence behind the headache tools.
15
acute migraine treatments
16
chronic preventive treatments
12
cluster treatments
5
first-line acute options
AHS grading
Headache pages use AHS A/B/C/U grading. It is not interchangeable with stroke COR/LOE.
A
Established effective (2+ Class I)
B
Probably effective (1 Class I or 2+ Class II)
C
Possibly effective (1 Class II or 2+ Class III)
U
Insufficient evidence
Acute Migraine -- Emergency Department
15 treatments organized by evidence tier. Contraindication-aware filtering based on patient comorbidities, pregnancy status, and medication history.
first-line: 5second-line: 7adjunct: 1avoid: 2
Open acute migraine →Chronic Migraine -- Preventive
16 preventive treatments including oral preventives, CGRP-targeted therapies, onabotulinumtoxinA, and neuromodulation. Current-regimen-aware sequencing with MOH-guided selection.
Open chronic migraine →Cluster Headache
AHS 2016 Guidelines
5 acute treatments and 7 prophylactic treatments. Phase-aware filtering with oxygen protocol guidance, ECG monitoring for verapamil, and episodic/chronic subtype awareness.
Open cluster headache →Grading note
AHS A/B/C/U levels are not equivalent to the AHA/ASA COR/LOE system used in the stroke workspace.